Biomechanical results obtained in joints allow us to obtain boudary conditions which can be used as input for mechanobiology experiments. We are particularly interested to identify the different phenomena which lead to an implant loosening when its mechanical environment has been characterized. For exemple, we found that a short term duration mechanical stimulus applied on fresh human bone induced an increase RANKL/OPG ratio, leading then to an increase in bone resorption. This information was then used to design a drug delivery system by proposing to control the osteoclast in delivering bisphosphonate.
We are also interested to evaluate osteogenic mechanical stimulation in scaffold by evaluating the effect of fluid-induced shear stress on cells through scaffold deformation. This kind of information is then used in the design of bone scaffold.
